Over the last two decades, deaths from overdose of Tramadol have increased considerably. Researchers at the U.S. Centers for Disease Control and Prevention (CDC) have found that the proportion of overdose deaths resulting from synthetic opioids like Tramadol have in fact increased from 10 percent in 2011 to 20 percent in 2016. Because many prescribers consider this medicine as a safe opioid than something more potent like morphine, people often disregard drug interaction warnings or dosage instructions. Those who have been abusing Tramadol build dependence over time. These people deliberately increase their doses in an unsafe manner so that they could continue to attain the high.
Signs and Symptoms of Overdose
Opioids work by tying to particular receptors in the mind and hindering the pain signals. They might also affect parts of central nervous system responsible for regulating breathing and reward responses. Taking too much could cause serious and even life-threatening adverse effects. However, Tramadol’s overall effect on archetypical opioid receptor is weak, when compared to other more distinctive opioids. But, the medicine also wields its analgesic effects with additional actions on serotonin and norepinephrine neurotransmitter.
Causes of Overdose
Drug dependence is actually a major danger factor for overdose. Though, general Tramadol dose has demonstrated to have a low potential for dependence and abuse than more strong opioids, such as hydrocodone or codeine, its abuse and misuse rate has in fact been escalating. In the year 2013, about 3.3 million individuals used this medication for non-medical purposes, up from 2.8 million in 2012, according to a new report by National Survey on Drug Use and Health (NSDUH). Moreover, NSDUH has also stated that some demographic factors might also play a role in the occurrence of an overdose. The majority of individuals, who abused this drug, were above the age of 25.
On the other hand, Drug Enforcement Administration in the U.S. has said that Tramadol is likely to be misused by people, who are health professionals, are chronic distress patients, or are already suffering from narcotic addiction. In general, men are likely to overdose, especially on prescription painkillers, though overdose rates in females have been rapidly increasing in recent years.
Prescription painkiller tolerance is in general related with dependency on other substances like alcohol. Individuals who have clambered with substance addiction may be more vulnerable to develop dependence on opioids, thus putting them at an increased risk of an overdose. Therefore, for best therapeutic results, buy Tramadol online after consulting with your medic, and take the doses correctly on time as instructed.